Rnf38 | ring finger protein 38
Physiological systems
21 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Vision/eye Behavior/neurological Mortality/aging Cardiovascular system
17 No significant impact
3 Not tested
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:49Adult tissues
62Embryo tissues
| unresponsive to tactile stimuli | 1 supporting dataset | Rnf38tm1b(KOMP)Wtsi | heterozygote | E18.5 | N/A * | ||
| decreased total retina thickness | 2 supporting datasets | Rnf38tm1b(KOMP)Wtsi | heterozygote | Early adult | 6.68x10-13 | ||
| preweaning lethality, incomplete penetrance | 3 supporting datasets | Rnf38tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Rnf38tm1b(KOMP)Wtsi | heterozygote | Early adult | 2.48x10-5 | ||
| unresponsive to tactile stimuli | 1 supporting dataset | Rnf38tm1b(KOMP)Wtsi | homozygote | E18.5 | N/A * |
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| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Rnf38 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Rnf38.
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| Rnf38tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Rnf38tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Rnf38tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |