Sgip1 | SH3-domain GRB2-like (endophilin) interacting protein 1
Physiological systems
19 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Integument Limbs/digits/tail Vision/eye Behavior/neurological Cardiovascular system
13 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:70Adult tissues
0Embryo tissues
| hyperactivity | 2 supporting datasets | Sgip1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.43x10-6 | ||
| increased startle reflex | 1 supporting dataset | Sgip1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.83x10-5 | ||
| abnormal digit morphology | 1 supporting dataset | Sgip1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.37x10-6 | ||
| increased circulating lipase level | 1 supporting dataset | Sgip1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.62x10-5 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Sgip1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 5.74x10-5 | ||
| abnormal nail morphology | 1 supporting dataset | Sgip1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.49x10-6 | ||
| abnormal lens morphology | 2 supporting datasets | Sgip1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.5x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
Human diseases caused by Sgip1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Sgip1.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Sgip1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Sgip1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Sgip1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Sgip1tm39126(L1L2_gt1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |