Phykpl | 5-phosphohydroxy-L-lysine phospholyase
Physiological systems
13 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Nervous system Vision/eye Behavior/neurological
9 No significant impact
11 Not tested
Data collections
Viability data
Body weight measurements
Embryo imaging data
Body weight measurements
Embryo imaging data
Gene metrics:8Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased circulating phosphate level | 1 supporting dataset | Phykpltm1a(EUCOMM)Wtsi | homozygote | Early adult | 5.78x10-8 | ||
| decreased circulating creatinine level | 1 supporting dataset | Phykpltm1a(EUCOMM)Wtsi | homozygote | Early adult | 5.63x10-13 | ||
| increased circulating calcium level | 1 supporting dataset | Phykpltm1a(EUCOMM)Wtsi | homozygote | Early adult | 5.47x10-7 | ||
| abnormal retina morphology | 4 supporting datasets | Phykpltm1a(EUCOMM)Wtsi | homozygote | Early adult | 9.66x10-6 | ||
| decreased prepulse inhibition | 1 supporting dataset | Phykpltm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.48x10-5 | ||
| increased startle reflex | 2 supporting datasets | Phykpltm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.47x10-10 | ||
| decreased circulating alkaline phosphatase level | 1 supporting dataset | Phykpltm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.92x10-9 | ||
| abnormal locomotor activation | 1 supporting dataset | Phykpltm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.65x10-6 |
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Human diseases caused by Phykpl mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Phykpl.
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| Phykpltm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Phykpltm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Phykpltm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Phykpltm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Phykpltm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |