Phykpl | 5-phosphohydroxy-L-lysine phospholyase

GeneMGI:1920197Synonyms: 2900006B13Rik, Agxt2l2

Physiological systems

13 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Nervous system Vision/eye Behavior/neurological

9 No significant impact

11 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating phosphate level	1 supporting dataset	Phykpl^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.78x10^-8
decreased circulating creatinine level	1 supporting dataset	Phykpl^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.63x10^-13
increased circulating calcium level	1 supporting dataset	Phykpl^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.47x10^-7
abnormal retina morphology	4 supporting datasets	Phykpl^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	9.66x10^-6
decreased prepulse inhibition	1 supporting dataset	Phykpl^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.48x10^-5
increased startle reflex	2 supporting datasets	Phykpl^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.47x10^-10
decreased circulating alkaline phosphatase level	1 supporting dataset	Phykpl^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.92x10^-9
abnormal locomotor activation	1 supporting dataset	Phykpl^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.65x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Phykpl.

Associated images

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Histopathology

There is no histopathology data found for Phykpl.

IMPC related publications

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External links

No external links available for Phykpl.

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*Phykpl^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Phykpl^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Phykpl^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Phykpl^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Phykpl^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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