Prdm4 | PR domain containing 4
Physiological systems
20 / 24 physiological systems tested
12 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Limbs/digits/tail Muscle Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Renal/urinary system
8 No significant impact
4 Not tested
Data collections
Gene metrics:14Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues
| impaired glucose tolerance | 1 supporting dataset | Prdm4tm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.16x10-6 | ||
| abnormal heart left ventricle morphology | 4 supporting datasets | Prdm4tm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.92x10-10 | ||
| microphthalmia | 1 supporting dataset | Prdm4tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| short tibia | 1 supporting dataset | Prdm4tm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.66x10-5 | ||
| abnormal cornea morphology | 1 supporting dataset | Prdm4tm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.81x10-6 | ||
| absent spleen | 1 supporting dataset | Prdm4tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| increased lean body mass | 1 supporting dataset | Prdm4tm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.98x10-7 | ||
| thick ventricular wall | 1 supporting dataset | Prdm4tm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.49x10-6 | ||
| abnormal gait | 1 supporting dataset | Prdm4tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.08x10-7 | ||
| abnormal iris morphology | 1 supporting dataset | Prdm4tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.48x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Prdm4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Prdm4.
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| Prdm4tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Prdm4tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Prdm4tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Prdm4tm1c(EUCOMM)Hmgu | Wild type floxed exon (post-Flp) | | mouse |
| Prdm4tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |