Lhfpl6 | LHFPL tetraspan subfamily member 6
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Integument Growth/size/body region Vision/eye Behavior/neurological Cardiovascular system
15 No significant impact
4 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| enlarged heart | 1 supporting dataset | Lhfpl6em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| decreased locomotor activity | 2 supporting datasets | Lhfpl6em1(IMPC)Mbp | homozygote | Early adult | 5.32x10-5 | ||
| microphthalmia | 1 supporting dataset | Lhfpl6em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal eye morphology | 1 supporting dataset | Lhfpl6em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal heart morphology | 1 supporting dataset | Lhfpl6em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| anophthalmia | 1 supporting dataset | Lhfpl6em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | Lhfpl6em1(IMPC)Mbp | homozygote | Early adult | N/A * |
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Human diseases caused by Lhfpl6 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Lhfpl6.
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| Lhfpl6em1(IMPC)Mbp | Intra-exon deletion | | mouse |
| Lhfpl6tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Lhfpl6tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |