Fam72a | family with sequence similarity 72, member A
Physiological systems
21 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Renal/urinary system
18 No significant impact
3 Not tested
Data collections
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| increased blood urea nitrogen level | 1 supporting dataset | Fam72atm1.1(KOMP)Vlcg | homozygote | Early adult | 2.86x10-5 | ||
| polycystic kidney | 1 supporting dataset | Fam72atm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| abnormal kidney morphology | 1 supporting dataset | Fam72atm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
Human diseases caused by Fam72a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Fam72a.
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| Fam72atm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Fam72atm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Fam72atm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Fam72atm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Fam72atm213517(L1L2_Bact_P) | Reporter-tagged deletion allele (with selection cassette) | | targeting vector |
| Fam72atm445845(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |