2210408I21Rik | RIKEN cDNA 2210408I21 gene
GeneMGI:1919621
Physiological systems
18 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Adipose tissue Growth/size/body region Nervous system Skeleton Renal/urinary system
11 No significant impact
6 Not tested
Data collections
Gene metrics:8Significant phenotypes
2Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| small superior vagus ganglion | 1 supporting dataset | 2210408I21Riktm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased total body fat amount | 2 supporting datasets | 2210408I21Riktm1b(EUCOMM)Wtsi | homozygote | Early adult | 8.71x10-9 | ||
| decreased bone mineral density | 1 supporting dataset | 2210408I21Riktm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.1x10-17 | ||
| decreased lean body mass | 1 supporting dataset | 2210408I21Riktm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.33x10-8 | ||
| hydrometra | 1 supporting dataset | 2210408I21Riktm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal kidney morphology | 1 supporting dataset | 2210408I21Riktm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| impaired glucose tolerance | 1 supporting dataset | 2210408I21Riktm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.64x10-5 | ||
| decreased bone mineral content | 2 supporting datasets | 2210408I21Riktm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.82x10-8 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 50% (1/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 50% (1/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images | 100% (2/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
Human diseases caused by 2210408I21Rik mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for 2210408I21Rik.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| 2210408I21Riktm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| 2210408I21Riktm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |