Iars2 | isoleucine-tRNA synthetase 2, mitochondrial
Physiological systems
20 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Vision/eye Hematopoietic system Mortality/aging
17 No significant impact
4 Not tested
Data collections
Gene metrics:5Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Iars2em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Iars2em1(IMPC)Tcp | homozygote | E9.5 | N/A * | ||
| prenatal lethality prior to heart atrial septation | 1 supporting dataset | Iars2em1(IMPC)Tcp | homozygote | E15.5 | N/A * | ||
| abnormal eye morphology | 1 supporting dataset | Iars2em1(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| increased hematocrit | 1 supporting dataset | Iars2em1(IMPC)Tcp | heterozygote | Early adult | 1.7x10-5 |
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External links
No external links available for Iars2.
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| Iars2em1(IMPC)Tcp | Exon Deletion | | mouse |
| Iars2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector es cell |
| Iars2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector es cell |
| Iars2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | es cell |