Fbxl2 | F-box and leucine-rich repeat protein 2

GeneMGI:1919429Synonyms: Fbl3, 2810423A21Rik

Physiological systems

18 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Immune system Hematopoietic system

16 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased mean corpuscular hemoglobin concentration1 supporting datasetFbxl2em2(IMPC)MarchomozygoteEarly adult2.39x10-13 
decreased red blood cell distribution width1 supporting datasetFbxl2em2(IMPC)MarchomozygoteEarly adult2.34x10-6 
increased mean corpuscular hemoglobin1 supporting datasetFbxl2em2(IMPC)MarchomozygoteEarly adult2.03x10-10 
increased mean corpuscular volume1 supporting datasetFbxl2em2(IMPC)MarchomozygoteEarly adult4.53x10-18 
increased hematocrit1 supporting datasetFbxl2em2(IMPC)MarchomozygoteEarly adult1.8x10-5 
increased hemoglobin content1 supporting datasetFbxl2em2(IMPC)MarchomozygoteEarly adult2.13x10-5 
increased basophil cell number1 supporting datasetFbxl2em2(IMPC)MarchomozygoteEarly adult1.25x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Fbxl2em2(IMPC)MarcDeletionmouse
Fbxl2tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Fbxl2tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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