Dusp11 | dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Behavior/neurological Cardiovascular system
15 No significant impact
5 Not tested
Data collections
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased total retina thickness | 2 supporting datasets | Dusp11tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.41x10-5 | ||
| abnormal cornea morphology | 1 supporting dataset | Dusp11tm1b(EUCOMM)Wtsi | homozygote | Early adult | 9.6x10-6 | ||
| abnormal locomotor behavior | 1 supporting dataset | Dusp11tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.83x10-6 | ||
| prolonged QRS complex duration | 1 supporting dataset | Dusp11tm1b(EUCOMM)Wtsi | homozygote | Early adult | 6.96x10-5 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Dusp11tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.83x10-5 |
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Human diseases caused by Dusp11 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Dusp11.
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| Dusp11tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Dusp11tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Dusp11tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Dusp11tm42136(L1L2_gt2) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |