Eef1akmt2 | EEF1A lysine methyltransferase 2
Physiological systems
17 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Vision/eye Behavior/neurological
15 No significant impact
7 Not tested
Data collections
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues
| persistence of hyaloid vascular system | 1 supporting dataset | Eef1akmt2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.31x10-6 | ||
| cataract | 1 supporting dataset | Eef1akmt2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 7.96x10-5 | ||
| impaired pupillary reflex | 1 supporting dataset | Eef1akmt2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.04x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Eef1akmt2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Eef1akmt2.
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| Eef1akmt2tm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Eef1akmt2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Eef1akmt2tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Eef1akmt2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |