Gpc2 | glypican 2 cerebroglycan
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Endocrine/exocrine gland Mortality/aging Cardiovascular system Renal/urinary system
15 No significant impact
5 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:42Adult tissues
0Embryo tissues
| small kidney | 1 supporting dataset | Gpc2tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| preweaning lethality, incomplete penetrance | 2 supporting datasets | Gpc2tm1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| preweaning lethality, incomplete penetrance | 2 supporting datasets | Gpc2tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| small adrenal glands | 1 supporting dataset | Gpc2tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| abnormal sinus arrhythmia | 1 supporting dataset | Gpc2tm1.1(KOMP)Vlcg | homozygote | Early adult | 5.02x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/1) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | Section images | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
| eye | heterozygote | n/a | 0% (0/2) | 0% (0/335) |
Human diseases caused by Gpc2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Gpc2.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Gpc2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Gpc2tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Gpc2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Gpc2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |