Plekhf2 | pleckstrin homology domain containing, family F (with FYVE domain) member 2
Physiological systems
21 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Hearing/vestibular/ear Hematopoietic system Behavior/neurological Renal/urinary system
15 No significant impact
3 Not tested
Data collections
Gene metrics:11Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal auditory brainstem response | 2 supporting datasets | Plekhf2em1(IMPC)Wtsi | homozygote | Early adult | 2.53x10-8 | ||
| increased circulating unsaturated transferrin level | 1 supporting dataset | Plekhf2em1(IMPC)Wtsi | homozygote | Early adult | 2.42x10-5 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Plekhf2em1(IMPC)Wtsi | homozygote | Early adult | 6.52x10-6 | ||
| decreased mean corpuscular hemoglobin | 1 supporting dataset | Plekhf2em1(IMPC)Wtsi | homozygote | Early adult | 3.39x10-15 | ||
| increased eosinophil cell number | 1 supporting dataset | Plekhf2em1(IMPC)Wtsi | homozygote | Early adult | 8.61x10-5 | ||
| decreased circulating HDL cholesterol level | 1 supporting dataset | Plekhf2em1(IMPC)Wtsi | homozygote | Early adult | 3.96x10-5 | ||
| decreased circulating cholesterol level | 1 supporting dataset | Plekhf2em1(IMPC)Wtsi | homozygote | Early adult | 3.49x10-5 | ||
| decreased mean corpuscular volume | 1 supporting dataset | Plekhf2em1(IMPC)Wtsi | homozygote | Early adult | 3.85x10-19 | ||
| small kidney | 1 supporting dataset | Plekhf2em1(IMPC)Wtsi | homozygote | Early adult | N/A * | ||
| decreased startle reflex | 1 supporting dataset | Plekhf2em1(IMPC)Wtsi | homozygote | Early adult | 3.43x10-6 |
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Human diseases caused by Plekhf2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Plekhf2.
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| Plekhf2em1(IMPC)Wtsi | Deletion | | mouse |
| Plekhf2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Plekhf2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Plekhf2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Plekhf2tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |