Dram1 | DNA-damage regulated autophagy modulator 1
Physiological systems
21 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Respiratory system Liver/biliary system Behavior/neurological
18 No significant impact
3 Not tested
Data collections
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| abnormal liver morphology | 1 supporting dataset | Dram1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| increased grip strength | 1 supporting dataset | Dram1tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.72x10-5 | ||
| abnormal lung morphology | 1 supporting dataset | Dram1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 50% (1/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/1) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
Human diseases caused by Dram1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Dram1.
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| Dram1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Dram1tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Dram1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Dram1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Dram1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |