Pex1 | peroxisomal biogenesis factor 1
Physiological systems
18 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Muscle Liver/biliary system Cardiovascular system Mortality/aging
14 No significant impact
6 Not tested
Data collections
Gene metrics:5Significant phenotypes
7Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased cardiac muscle contractility | 2 supporting datasets | Pex1tm1e.1(EUCOMM)Hmgu | heterozygote | Early adult | 1.03x10-6 | ||
| decreased heart rate | 1 supporting dataset | Pex1tm1e.1(EUCOMM)Hmgu | heterozygote | Early adult | 2.31x10-8 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Pex1tm1e.1(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| dilated heart left ventricle | 2 supporting datasets | Pex1tm1e.1(EUCOMM)Hmgu | heterozygote | Early adult | 2.2x10-7 | ||
| abnormal liver morphology | 1 supporting dataset | Pex1tm1e.1(EUCOMM)Hmgu | heterozygote | Early adult | N/A * |
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Human diseases caused by Pex1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Pex1.
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| Pex1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Pex1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell mouse |
| Pex1tm1e.1(EUCOMM)Hmgu | Promoter excision from Targeted, non-conditional allele | | mouse |
| Pex1tm46430(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |