Dlg5 | discs large MAGUK scaffold protein 5
Physiological systems
23 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Nervous system Vision/eye Craniofacial Mortality/aging Cardiovascular system
15 No significant impact
1 Not tested
Gene metrics:9Significant phenotypes
1Associated diseases
Expression examined in:73Adult tissues
104Embryo tissues
| hydrocephaly | 1 supporting dataset | Dlg5tm1b(EUCOMM)Wtsi | heterozygote | Early adult | N/A * | ||
| abnormal brain morphology | 1 supporting dataset | Dlg5tm1b(EUCOMM)Wtsi | heterozygote | Early adult | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Dlg5tm1b(EUCOMM)Wtsi | homozygote | E15.5 | N/A * | ||
| microphthalmia | 1 supporting dataset | Dlg5tm1b(EUCOMM)Wtsi | homozygote | E15.5 | N/A * | ||
| spina bifida | 1 supporting dataset | Dlg5tm1b(EUCOMM)Wtsi | heterozygote | E15.5 | N/A * | ||
| hemorrhage | 1 supporting dataset | Dlg5tm1b(EUCOMM)Wtsi | homozygote | E15.5 | N/A * | ||
| hemorrhage | 1 supporting dataset | Dlg5tm1b(EUCOMM)Wtsi | heterozygote | E15.5 | N/A * | ||
| spina bifida | 1 supporting dataset | Dlg5tm1b(EUCOMM)Wtsi | homozygote | E15.5 | N/A * | ||
| abnormal craniofacial morphology | 1 supporting dataset | Dlg5tm1b(EUCOMM)Wtsi | homozygote | E15.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Dlg5tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 50% (1/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images | 50% (1/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 50% (1/2) | 0.56% (3/532) |
Human diseases caused by Dlg5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Dlg5.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Dlg5tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Dlg5tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Dlg5tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |