Setd2 | SET domain containing 2
Physiological systems
17 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Limbs/digits/tail Nervous system Behavior/neurological Skeleton Cardiovascular system
12 No significant impact
7 Not tested
Data collections
Gene metrics:7Significant phenotypes
5Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased exploration in new environment | 1 supporting dataset | Setd2tm1b(NCOM)Mfgc | homozygote | Early adult | 9.18x10-5 | ||
| short tibia | 1 supporting dataset | Setd2tm1b(NCOM)Mfgc | homozygote | Early adult | 7.21x10-9 | ||
| prolonged QRS complex duration | 1 supporting dataset | Setd2tm1b(NCOM)Mfgc | homozygote | Early adult | 1.96x10-5 | ||
| decreased prepulse inhibition | 2 supporting datasets | Setd2tm1b(NCOM)Mfgc | homozygote | Early adult | 3.36x10-7 | ||
| increased grip strength | 1 supporting dataset | Setd2tm1b(NCOM)Mfgc | homozygote | Early adult | 9.87x10-5 |
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Human diseases caused by Setd2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Setd2.
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| Setd2tm1a(NCOM)Mfgc | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Setd2tm1b(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | mouse |