Wars2 | tryptophanyl tRNA synthetase 2 (mitochondrial)
Physiological systems
19 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Nervous system Mortality/aging
17 No significant impact
5 Not tested
Data collections
Gene metrics:4Significant phenotypes
3Associated diseases
Expression examined in:49Adult tissues
21Embryo tissues
| embryonic lethality prior to organogenesis | 1 supporting dataset | Wars2tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| abnormal spinal cord morphology | 1 supporting dataset | Wars2tm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Wars2tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Wars2tm1.1(KOMP)Vlcg | homozygote | E12.5 | N/A * |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone marrow | heterozygote | Section images | 100% (1/1) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
Human diseases caused by Wars2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Wars2.
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