Cyp4f16 | cytochrome P450, family 4, subfamily f, polypeptide 16
Physiological systems
19 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Behavior/neurological
16 No significant impact
5 Not tested
Data collections
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:51Adult tissues
42Embryo tissues
| increased fasting circulating glucose level | 1 supporting dataset | Cyp4f16tm1b(KOMP)Wtsi | homozygote | Early adult | 2.79x10-7 | ||
| decreased total retina thickness | 1 supporting dataset | Cyp4f16tm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.02x10-5 | ||
| limb grasping | 1 supporting dataset | Cyp4f16tm1b(KOMP)Wtsi | homozygote | Early adult | 5.08x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Wholemount images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Wholemount images | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | Wholemount images | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Wholemount images | 100% (2/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 100% (1/1) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
Human diseases caused by Cyp4f16 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cyp4f16.
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| Cyp4f16tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Cyp4f16tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Cyp4f16tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Cyp4f16tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Cyp4f16tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Cyp4f16tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |