Sec24d | SEC24 homolog D, COPII coat complex component
Physiological systems
20 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Digestive/alimentary Liver/biliary system Mortality/aging
16 No significant impact
4 Not tested
Data collections
Gene metrics:4Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 1 supporting dataset | Sec24dem1(IMPC)Rbrc | homozygote | Early adult | N/A * | ||
| impaired glucose tolerance | 1 supporting dataset | Sec24dem1(IMPC)Rbrc | heterozygote | Early adult | 5.79x10-10 | ||
| abnormal liver morphology | 1 supporting dataset | Sec24dem1(IMPC)Rbrc | heterozygote | Early adult | N/A * | ||
| abnormal stomach morphology | 1 supporting dataset | Sec24dem1(IMPC)Rbrc | heterozygote | Early adult | N/A * |
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Human diseases caused by Sec24d mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Sec24d.
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| Sec24dem1(IMPC)Rbrc | Exon Deletion | | mouse |
| Sec24dtm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Sec24dtm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |