Pcgf3 | polycomb group ring finger 3
Physiological systems
16 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Embryo Growth/size/body region Limbs/digits/tail Nervous system Digestive/alimentary Vision/eye Behavior/neurological Mortality/aging Craniofacial
7 No significant impact
8 Not tested
Data collections
Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| cleft palate | 1 supporting dataset | Pcgf3em1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Pcgf3em1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| abnormal tail morphology | 1 supporting dataset | Pcgf3em1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| decreased prepulse inhibition | 2 supporting datasets | Pcgf3em1(IMPC)Bay | heterozygote | Early adult | 5.47x10-5 | ||
| abnormal embryo size | 1 supporting dataset | Pcgf3em1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| polydactyly | 1 supporting dataset | Pcgf3em1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| hyperactivity | 2 supporting datasets | Pcgf3em1(IMPC)Bay | heterozygote | Early adult | 2.78x10-5 | ||
| facial cleft | 1 supporting dataset | Pcgf3em1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| syndactyly | 1 supporting dataset | Pcgf3em1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| abnormal facial morphology | 2 supporting datasets | Pcgf3em1(IMPC)Bay | homozygote | E18.5 | N/A * |
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Human diseases caused by Pcgf3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Pcgf3.
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| Pcgf3em1(IMPC)Bay | Exon Deletion | | mouse |
| Pcgf3tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Pcgf3tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |