Klk10 | kallikrein related-peptidase 10
Physiological systems
21 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Immune system Endocrine/exocrine gland Hematopoietic system Cardiovascular system
17 No significant impact
3 Not tested
Data collections
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| enlarged thymus | 1 supporting dataset | Klk10em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal sinus arrhythmia | 1 supporting dataset | Klk10em1(IMPC)Ccpcz | homozygote | Early adult | 1.79x10-11 | ||
| decreased hematocrit | 1 supporting dataset | Klk10em1(IMPC)Ccpcz | homozygote | Early adult | 9.28x10-5 | ||
| decreased hemoglobin content | 1 supporting dataset | Klk10em1(IMPC)Ccpcz | homozygote | Early adult | 4.57x10-5 | ||
| abnormal thymus morphology | 1 supporting dataset | Klk10em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| increased effector memory CD8-positive, alpha-beta T cell number | 1 supporting dataset | Klk10em1(IMPC)Ccpcz | homozygote | Early adult | 2.3x10-20 | ||
| cardiovascular system phenotype | 1 supporting dataset | Klk10em1(IMPC)Ccpcz | homozygote | Early adult | 4.08x10-6 | ||
| increased effector memory T-helper cell number | 1 supporting dataset | Klk10em1(IMPC)Ccpcz | homozygote | Early adult | 3.6x10-5 | ||
| decreased CD8-positive, naive alpha-beta T cell number | 1 supporting dataset | Klk10em1(IMPC)Ccpcz | homozygote | Early adult | 5.14x10-5 |
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Human diseases caused by Klk10 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Klk10.
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| Klk10em1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Klk10tm1(EGFP/cre/ERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Klk10tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Klk10tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |