Avpi1 | arginine vasopressin-induced 1
Physiological systems
18 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Muscle Hearing/vestibular/ear Cardiovascular system
15 No significant impact
6 Not tested
Data collections
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:70Adult tissues
0Embryo tissues
| increased cardiac muscle contractility | 2 supporting datasets | Avpi1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.34x10-5 | ||
| increased heart rate variability | 1 supporting dataset | Avpi1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.12x10-8 | ||
| abnormal auditory brainstem response | 2 supporting datasets | Avpi1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.35x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
Human diseases caused by Avpi1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Avpi1.
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| Avpi1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Avpi1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Avpi1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Avpi1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |