Tmem127 | transmembrane protein 127

GeneMGI:1916720Synonyms: 2310003P10Rik

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Obsolete increased cd8-positive, alpha beta t cell number Hematopoietic system Behavior/neurological Skeleton

12 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:29Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating bilirubin level	1 supporting dataset	Tmem127^{tm1(KOMP)Wtsi}	homozygote	Early adult	5.48x10^-5
decreased effector memory CD8-positive, alpha-beta T cell number	2 supporting datasets	Tmem127^{tm1(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased monocyte cell number	2 supporting datasets	Tmem127^{tm1(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased neutrophil cell number	2 supporting datasets	Tmem127^{tm1(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating amylase level	1 supporting dataset	Tmem127^{tm1(KOMP)Wtsi}	homozygote	Early adult	6.3x10^-10
increased bone mineral content	1 supporting dataset	Tmem127^{tm1(KOMP)Wtsi}	homozygote	Early adult	2.59x10^-5
thrombocytopenia	1 supporting dataset	Tmem127^{tm1(KOMP)Wtsi}	homozygote	Early adult	2.28x10^-7
decreased B cell number	1 supporting dataset	Tmem127^{tm1(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
obsolete increased CD8-positive, alpha beta T cell number	2 supporting datasets	Tmem127^{tm1(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased KLRG1-positive NK cell number	1 supporting dataset	Tmem127^{tm1(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tmem127.

Associated images

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Histopathology

There is no histopathology data found for Tmem127.

IMPC related publications

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External links

No external links available for Tmem127.

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*Tmem127^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Tmem127^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell mouse
*Tmem127^{tm444523(L1L2_GT1_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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