Ppp1r12b | protein phosphatase 1, regulatory subunit 12B
Physiological systems
17 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Integument Cardiovascular system
15 No significant impact
7 Not tested
Data collections
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal coat/ hair morphology | 1 supporting dataset | Ppp1r12bem1(IMPC)J | homozygote | Early adult | 3.1x10-11 | ||
| decreased heart weight | 1 supporting dataset | Ppp1r12bem1(IMPC)J | homozygote | Early adult | 5.05x10-8 | ||
| absent vibrissae | 1 supporting dataset | Ppp1r12bem1(IMPC)J | homozygote | Early adult | 7.78x10-11 |
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Human diseases caused by Ppp1r12b mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ppp1r12b.
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| Ppp1r12bem1(IMPC)J | Exon Deletion | | mouse |
| Ppp1r12btm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Ppp1r12btm271260(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |