Ccdc124 | coiled-coil domain containing 124
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Immune system Nervous system Respiratory system Liver/biliary system Hematopoietic system Behavior/neurological Cardiovascular system
13 No significant impact
4 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased brain size | 2 supporting datasets | Ccdc124tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| small lung | 2 supporting datasets | Ccdc124tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| small heart | 2 supporting datasets | Ccdc124tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| small liver | 2 supporting datasets | Ccdc124tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| small spleen | 2 supporting datasets | Ccdc124tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| hyperactivity | 1 supporting dataset | Ccdc124tm1b(KOMP)Wtsi | homozygote | Early adult | 1.22x10-7 | ||
| decreased exploration in new environment | 1 supporting dataset | Ccdc124tm1b(KOMP)Wtsi | homozygote | Early adult | 1.04x10-9 |
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Human diseases caused by Ccdc124 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ccdc124.
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| Ccdc124tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ccdc124tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ccdc124tm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |
| Ccdc124tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |