Adamts9 | ADAM metallopeptidase with thrombospondin type 1 motif 9
Physiological systems
22 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Immune system Embryo Growth/size/body region Vision/eye Mortality/aging
17 No significant impact
2 Not tested
Data collections
Gene metrics:7Significant phenotypes
1Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| embryonic growth retardation | 1 supporting dataset | Adamts9tm1b(KOMP)Wtsi | heterozygote | E9.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Adamts9tm1b(KOMP)Wtsi | heterozygote | E9.5 | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Adamts9tm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| abnormal lymph node morphology | 1 supporting dataset | Adamts9tm1b(KOMP)Wtsi | heterozygote | Early adult | N/A * | ||
| abnormal eye morphology | 1 supporting dataset | Adamts9tm1b(KOMP)Wtsi | heterozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Adamts9tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| preweaning lethality, incomplete penetrance | 2 supporting datasets | Adamts9tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/1) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/1) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/1) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
Human diseases caused by Adamts9 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Adamts9.
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| Adamts9tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Adamts9tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Adamts9tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell mouse |