Chmp2b | charged multivesicular body protein 2B
Physiological systems
22 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Liver/biliary system Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging Renal/urinary system
11 No significant impact
2 Not tested
Data collections
Gene metrics:14Significant phenotypes
5Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| no spontaneous movement | 2 supporting datasets | Chmp2bem1(IMPC)Mbp | homozygote | E18.5 | N/A * | ||
| abnormal spleen morphology | 2 supporting datasets | Chmp2bem1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| no spontaneous movement | 2 supporting datasets | Chmp2bem1(IMPC)Mbp | heterozygote | E18.5 | N/A * | ||
| abnormal kidney morphology | 1 supporting dataset | Chmp2bem1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| enlarged spleen | 2 supporting datasets | Chmp2bem1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| prolonged RR interval | 1 supporting dataset | Chmp2bem1(IMPC)Mbp | heterozygote | Early adult | 9.35x10-6 | ||
| decreased heart rate | 1 supporting dataset | Chmp2bem1(IMPC)Mbp | heterozygote | Early adult | 5.08x10-5 | ||
| hydrometra | 1 supporting dataset | Chmp2bem1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| preweaning lethality, incomplete penetrance | 2 supporting datasets | Chmp2bem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| small kidney | 1 supporting dataset | Chmp2bem1(IMPC)Mbp | heterozygote | Late adult | N/A * |
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Human diseases caused by Chmp2b mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Chmp2b.
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| Chmp2bem1(IMPC)Mbp | Exon Deletion | | mouse |
| Chmp2btm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Chmp2btm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |