Pygo2 | pygopus 2
Physiological systems
21 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Limbs/digits/tail Nervous system Vision/eye Cardiovascular system Mortality/aging Craniofacial Renal/urinary system
12 No significant impact
3 Not tested
Gene metrics:13Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
29Embryo tissues
| abnormal hindbrain morphology | 1 supporting dataset | Pygo2tm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Pygo2tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| edema | 1 supporting dataset | Pygo2tm1b(EUCOMM)Wtsi | homozygote | E15.5 | N/A * | ||
| abnormal neural tube closure | 1 supporting dataset | Pygo2tm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| hemorrhage | 1 supporting dataset | Pygo2tm1b(EUCOMM)Wtsi | homozygote | E15.5 | N/A * | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Pygo2tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.27x10-5 | ||
| abnormal midbrain morphology | 1 supporting dataset | Pygo2tm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| abnormal limb morphology | 1 supporting dataset | Pygo2tm1b(EUCOMM)Wtsi | homozygote | E15.5 | N/A * | ||
| anophthalmia | 1 supporting dataset | Pygo2tm1b(EUCOMM)Wtsi | homozygote | E15.5 | N/A * | ||
| microphthalmia | 1 supporting dataset | Pygo2tm1b(EUCOMM)Wtsi | homozygote | E15.5 | N/A * |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 50% (1/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images | 100% (1/1) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
Human diseases caused by Pygo2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Pygo2.
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| Pygo2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Pygo2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Pygo2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Pygo2tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Pygo2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Pygo2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |