Arb2a | ARB2 cotranscriptional regulator A

GeneMGI:1915925Synonyms: Fam172a, 53-E6, +4 more

Physiological systems

21 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Endocrine/exocrine gland Liver/biliary system Hematopoietic system Behavior/neurological

15 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating aspartate transaminase level	1 supporting dataset	Arb2a^{em2(IMPC)Ccpcz}	homozygote	Early adult	4.59x10^-5
decreased Ly6C-positive NK T cell number	1 supporting dataset	Arb2a^{em2(IMPC)Ccpcz}	homozygote	Early adult	1.2x10^-7
abnormal liver morphology	1 supporting dataset	Arb2a^{em2(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal thymus morphology	1 supporting dataset	Arb2a^{em2(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged thymus	1 supporting dataset	Arb2a^{em2(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal freezing behavior	1 supporting dataset	Arb2a^{em2(IMPC)Ccpcz}	homozygote	Early adult	3.59x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Arb2a.

Associated images

17 images

X-ray

XRay Images Forepaw

34 images

X-ray

XRay Images Hind Leg and Hip

17 images

X-ray

XRay Images Skull Dorso Ventral Orientation

17 images

X-ray

XRay Images Skull Lateral Orientation

34 images

X-ray

XRay Images Whole Body Dorso Ventral

17 images

X-ray

XRay Images Whole Body Lateral Orientation

Human diseases caused by Arb2a mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.



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Histopathology

There is no histopathology data found for Arb2a.

IMPC related publications

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External links

No external links available for Arb2a.

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*Arb2a^{em1(IMPC)Mhzh}*	Indel	‌	mouse
*Arb2a^{em2(IMPC)Ccpcz}*	Indel	‌	mouse

My Genes

Arb2a | ARB2 cotranscriptional regulator A

Physiological systems

6 Significantly impacted by the knock-out

15 No significant impact

3 Not tested

Data collections

Phenotypes

lacZ Expression

Associated images

X-ray

X-ray

X-ray

X-ray

X-ray

X-ray

Human diseases caused by Arb2a mutations

Histopathology

IMPC related publications

External links

Order Mouse and ES Cells

The IMPC Newsletter

Access Data Release 22.1 Data