Klk5 | kallikrein related-peptidase 5
Physiological systems
20 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Limbs/digits/tail Hearing/vestibular/ear Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system
12 No significant impact
4 Not tested
Data collections
Gene metrics:11Significant phenotypes
0Associated diseases
Expression examined in:78Adult tissues
36Embryo tissues
| abnormal vitreous body morphology | 1 supporting dataset | Klk5tm2b(KOMP)Wtsi | homozygote | Early adult | 1.27x10-7 | ||
| decreased mean corpuscular hemoglobin concentration | 1 supporting dataset | Klk5tm2b(KOMP)Wtsi | homozygote | Early adult | 6.72x10-9 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Klk5tm2b(KOMP)Wtsi | homozygote | Early adult | 3.61x10-5 | ||
| abnormal auditory brainstem response | 3 supporting datasets | Klk5tm2b(KOMP)Wtsi | homozygote | Early adult | 1.32x10-8 | ||
| increased red blood cell distribution width | 1 supporting dataset | Klk5tm2b(KOMP)Wtsi | homozygote | Early adult | 1.39x10-7 | ||
| long tibia | 1 supporting dataset | Klk5tm2b(KOMP)Wtsi | homozygote | Early adult | 2.57x10-11 | ||
| decreased total retina thickness | 1 supporting dataset | Klk5tm2b(KOMP)Wtsi | homozygote | Early adult | 4.29x10-6 | ||
| abnormal retina morphology | 1 supporting dataset | Klk5tm2b(KOMP)Wtsi | homozygote | Early adult | 2.9x10-12 | ||
| decreased locomotor activity | 1 supporting dataset | Klk5tm2b(KOMP)Wtsi | homozygote | Early adult | 7.4x10-5 | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Klk5tm2b(KOMP)Wtsi | homozygote | Early adult | 6.01x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | n/a | 0% (0/17) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | n/a | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
Human diseases caused by Klk5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Klk5.
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| Klk5tm1(EGFP/cre/ERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Klk5tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Klk5tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Klk5tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Klk5tm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Klk5tm2b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Klk5tm2e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |