Fbxw9 | F-box and WD-40 domain protein 9
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Immune system Endocrine/exocrine gland Vision/eye Respiratory system Hematopoietic system Behavior/neurological Mortality/aging
13 No significant impact
4 Not tested
Data collections
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:49Adult tissues
0Embryo tissues
| preweaning lethality, incomplete penetrance | 2 supporting datasets | Fbxw9tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased grip strength | 1 supporting dataset | Fbxw9tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 4.57x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Fbxw9tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| anophthalmia | 1 supporting dataset | Fbxw9tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal trachea morphology | 1 supporting dataset | Fbxw9tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal spleen morphology | 1 supporting dataset | Fbxw9tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| absent lymph nodes | 1 supporting dataset | Fbxw9tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal thyroid gland morphology | 1 supporting dataset | Fbxw9tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| absent spleen | 1 supporting dataset | Fbxw9tm1a(EUCOMM)Wtsi | heterozygote | Early adult | N/A * |
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| adrenal gland | heterozygote | Wholemount images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Wholemount images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Fbxw9 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Fbxw9.
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| Fbxw9tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Fbxw9tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Fbxw9tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |