Qars1 | glutaminyl-tRNA synthetase 1
Physiological systems
23 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Integument Muscle Nervous system Vision/eye Mortality/aging
18 No significant impact
1 Not tested
Data collections
Gene metrics:9Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal skin morphology | 1 supporting dataset | Qars1em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal skeletal muscle morphology | 1 supporting dataset | Qars1em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Qars1em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| anophthalmia | 1 supporting dataset | Qars1em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Qars1em1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| abnormal eye morphology | 2 supporting datasets | Qars1em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Qars1em1(IMPC)Mbp | heterozygote | Early adult | 7.59x10-7 | ||
| abnormal brain morphology | 1 supporting dataset | Qars1em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal retina morphology | 1 supporting dataset | Qars1em1(IMPC)Mbp | heterozygote | Early adult | 1.05x10-5 |
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Human diseases caused by Qars1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Qars1.
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| Qars1em1(IMPC)Mbp | Inter-exon deletion | | mouse |
| Qars1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Qars1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Qars1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Qars1tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |