Ndufs3 | NADH:ubiquinone oxidoreductase core subunit S3

GeneMGI:1915599Synonyms: 0610010M09Rik

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

2Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased circulating serum albumin level	1 supporting dataset	Ndufs3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.92x10^-6
decreased erythrocyte cell number	1 supporting dataset	Ndufs3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	6.16x10^-5
increased heart weight	1 supporting dataset	Ndufs3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	9.54x10^-16
preweaning lethality, complete penetrance	1 supporting dataset	Ndufs3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased total body fat amount	1 supporting dataset	Ndufs3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.77x10^-7
decreased circulating HDL cholesterol level	1 supporting dataset	Ndufs3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.51x10^-6
decreased circulating cholesterol level	1 supporting dataset	Ndufs3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.93x10^-6
increased startle reflex	2 supporting datasets	Ndufs3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.06x10^-5
increased circulating phosphate level	1 supporting dataset	Ndufs3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	5.04x10^-6
increased circulating sodium level	1 supporting dataset	Ndufs3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.31x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ndufs3.

Associated images

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Histopathology

There is no histopathology data found for Ndufs3.

IMPC related publications

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External links

No external links available for Ndufs3.

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*Ndufs3^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Ndufs3^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ndufs3^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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