Ndufs3 | NADH:ubiquinone oxidoreductase core subunit S3
Physiological systems
21 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging
14 No significant impact
3 Not tested
Data collections
Gene metrics:14Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| decreased circulating serum albumin level | 1 supporting dataset | Ndufs3tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 2.92x10-6 | ||
| decreased erythrocyte cell number | 1 supporting dataset | Ndufs3tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 6.16x10-5 | ||
| increased heart weight | 1 supporting dataset | Ndufs3tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 9.54x10-16 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Ndufs3tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| decreased total body fat amount | 1 supporting dataset | Ndufs3tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 1.77x10-7 | ||
| decreased circulating HDL cholesterol level | 1 supporting dataset | Ndufs3tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 4.51x10-6 | ||
| decreased circulating cholesterol level | 1 supporting dataset | Ndufs3tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 4.93x10-6 | ||
| increased startle reflex | 2 supporting datasets | Ndufs3tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 2.06x10-5 | ||
| increased circulating phosphate level | 1 supporting dataset | Ndufs3tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 5.04x10-6 | ||
| increased circulating sodium level | 1 supporting dataset | Ndufs3tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 3.31x10-5 |
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| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 100% (2/2) | 0% (0/173) |
| bone | heterozygote | n/a | n/a | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Ndufs3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Ndufs3.
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| Ndufs3tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Ndufs3tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ndufs3tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |