Leprotl1 | leptin receptor overlapping transcript-like 1
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Muscle Behavior/neurological Cardiovascular system
15 No significant impact
5 Not tested
Data collections
Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| decreased locomotor activity | 2 supporting datasets | Leprotl1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.22x10-7 | ||
| decreased anxiety-related response | 1 supporting dataset | Leprotl1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.68x10-5 | ||
| increased cardiac muscle contractility | 1 supporting dataset | Leprotl1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 9.87x10-5 | ||
| thick ventricular wall | 1 supporting dataset | Leprotl1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.04x10-6 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Leprotl1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.79x10-7 | ||
| increased circulating phosphate level | 1 supporting dataset | Leprotl1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.87x10-5 | ||
| abnormal behavior | 1 supporting dataset | Leprotl1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.89x10-5 | ||
| decreased thigmotaxis | 2 supporting datasets | Leprotl1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.32x10-7 | ||
| limb grasping | 1 supporting dataset | Leprotl1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.91x10-5 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Leprotl1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.35x10-9 |
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| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Leprotl1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Leprotl1.
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| Leprotl1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Leprotl1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Leprotl1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |