Pclaf | PCNA clamp associated factor

GeneMGI:1915276Synonyms: p15(PAF), 2810417H13Rik

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system

15 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased plasmacytoid dendritic cell number	4 supporting datasets	Pclaf^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
impaired glucose tolerance	1 supporting dataset	Pclaf^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.85x10^-5
increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number	3 supporting datasets	Pclaf^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased CD11b-high dendritic cell number	2 supporting datasets	Pclaf^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased dendritic cell number	2 supporting datasets	Pclaf^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased regulatory T cell number	2 supporting datasets	Pclaf^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased immature NK cell number	2 supporting datasets	Pclaf^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased mature NK cell number	1 supporting dataset	Pclaf^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased pro-B cell number	2 supporting datasets	Pclaf^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased T cell number	1 supporting dataset	Pclaf^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* Does not have a P-value assigned because it was manually marked as significant.

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lacZ Expression

No adult expression data available for Pclaf.

Associated images

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Histopathology

There is no histopathology data found for Pclaf.

IMPC related publications

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External links

No external links available for Pclaf.

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*Pclaf^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Pclaf^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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