Zwilch | zwilch kinetochore protein
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Hematopoietic system Mortality/aging Cardiovascular system
14 No significant impact
4 Not tested
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:49Adult tissues
50Embryo tissues
| abnormal placenta vasculature | 1 supporting dataset | Zwilchtm1.1(KOMP)Vlcg | homozygote | E12.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Zwilchtm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| decreased circulating iron level | 1 supporting dataset | Zwilchtm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.83x10-6 | ||
| abnormal placenta size | 1 supporting dataset | Zwilchtm1.1(KOMP)Vlcg | homozygote | E12.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Zwilchtm1.1(KOMP)Vlcg | homozygote | E12.5 | N/A * | ||
| abnormal placenta morphology | 1 supporting dataset | Zwilchtm1.1(KOMP)Vlcg | homozygote | E12.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Zwilchtm1.1(KOMP)Vlcg | homozygote | E12.5 | N/A * | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Zwilchtm1.1(KOMP)Vlcg | heterozygote | Early adult | 5.32x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| bone marrow | heterozygote | Section images | 100% (2/2) | 0% (0/22) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (1/1) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
Human diseases caused by Zwilch mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Zwilch.
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| Zwilchtm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Zwilchtm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Zwilchtm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Zwilchtm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Zwilchtm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Zwilchtm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |