Kat8 | K(lysine) acetyltransferase 8
Physiological systems
21 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Vision/eye Liver/biliary system Behavior/neurological Mortality/aging Renal/urinary system
14 No significant impact
3 Not tested
Data collections
Gene metrics:11Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| cataract | 1 supporting dataset | Kat8em1(IMPC)Mbp | heterozygote | Early adult | 9.23x10-5 | ||
| abnormal kidney morphology | 1 supporting dataset | Kat8em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Kat8em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Kat8em1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| small kidney | 1 supporting dataset | Kat8em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| increased circulating cholesterol level | 1 supporting dataset | Kat8em1(IMPC)Mbp | heterozygote | Early adult | 6.88x10-6 | ||
| enlarged lymph nodes | 1 supporting dataset | Kat8em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal lymph node morphology | 1 supporting dataset | Kat8em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| decreased locomotor activity | 1 supporting dataset | Kat8em1(IMPC)Mbp | heterozygote | Early adult | 1.21x10-7 | ||
| abnormal vitreous body morphology | 1 supporting dataset | Kat8em1(IMPC)Mbp | heterozygote | Early adult | 7.3x10-5 |
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Human diseases caused by Kat8 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Kat8.
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| Kat8em1(IMPC)Mbp | Inter-exon deletion | | mouse |
| Kat8tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Kat8tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |