Dctn4 | dynactin 4
Physiological systems
18 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Homeostasis/metabolism Mortality/aging
16 No significant impact
6 Not tested
Data collections
Gene metrics:2Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 1 supporting dataset | Dctn4em1(IMPC)Wtsi | homozygote | Early adult | N/A * | ||
| increased circulating free fatty acids level | 1 supporting dataset | Dctn4em1(IMPC)Wtsi | heterozygote | Early adult | 8.38x10-5 |
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Human diseases caused by Dctn4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Dctn4.
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| Dctn4em1(IMPC)Wtsi | Deletion | | mouse |
| Dctn4tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Dctn4tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Dctn4tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |