Elp1 | elongator complex protein 1
Physiological systems
20 / 24 physiological systems tested
1 Significantly impacted by the knock-out
Mortality/aging
19 No significant impact
4 Not tested
Data collections
Gene metrics:1Significant phenotypes
3Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 2 supporting datasets | Elp1tm1a(KOMP)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | n/a | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/1) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Elp1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Elp1.
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| Elp1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Elp1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Elp1tm36168(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |