Taok1 | TAO kinase 1
Physiological systems
20 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Integument Vision/eye Mortality/aging Cardiovascular system
16 No significant impact
4 Not tested
Data collections
Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| cataract | 1 supporting dataset | Taok1em1(IMPC)Tcp | heterozygote | Early adult | 2.97x10-5 | ||
| preweaning lethality, complete penetrance | 2 supporting datasets | Taok1em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Taok1em1(IMPC)Tcp | heterozygote | Early adult | 3.92x10-5 | ||
| abnormal lens morphology | 1 supporting dataset | Taok1em1(IMPC)Tcp | heterozygote | Early adult | 1.95x10-5 | ||
| abnormal skin morphology | 1 supporting dataset | Taok1em1(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Taok1em1(IMPC)Tcp | heterozygote | Early adult | 4.85x10-5 |
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Human diseases caused by Taok1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Taok1.
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| Taok1em1(IMPC)Tcp | Exon Deletion | | mouse |
| Taok1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Taok1tm1(NCOM)Cmhd | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |