Cul4a | cullin 4A
Physiological systems
21 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Vision/eye Hematopoietic system Behavior/neurological
15 No significant impact
3 Not tested
Data collections
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:78Adult tissues
35Embryo tissues
small testis | 1 supporting dataset | Cul4atm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
abnormal retina morphology | 1 supporting dataset | Cul4atm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.59x10-9 | ||
abnormal testis morphology | 1 supporting dataset | Cul4atm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
increased circulating potassium level | 1 supporting dataset | Cul4atm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.01x10-5 | ||
decreased circulating chloride level | 1 supporting dataset | Cul4atm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.59x10-7 | ||
enhanced cued conditioning behavior | 1 supporting dataset | Cul4atm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.29x10-8 | ||
male infertility | 1 supporting dataset | Cul4atm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
increased fasting circulating glucose level | 1 supporting dataset | Cul4atm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.91x10-5 | ||
decreased mean platelet volume | 1 supporting dataset | Cul4atm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.54x10-5 |
‌ | ‌ | ‌ | ‌ | ‌ | ‌ | ‌ | ‌ | ‌ | ‌ |
adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
blood | heterozygote | n/a | n/a | 0% (0/17) |
bone | heterozygote | Section images | 100% (2/2) | 0% (0/394) |
bone marrow | heterozygote | n/a | n/a | 0% (0/22) |
brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
cecum | heterozygote | Section images | 100% (2/2) | 7.75% (22/284) |
Human diseases caused by Cul4a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cul4a.
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Cul4atm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | ‌ | targeting vector ES Cell mouse |
Cul4atm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | ‌ | mouse |
Cul4atm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ‌ | ES Cell |