Cul4a | cullin 4A

GeneMGI:1914487Synonyms: 2810470J21Rik

Physiological systems

21 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Vision/eye Hematopoietic system Behavior/neurological

15 No significant impact

3 Not tested

Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:78Adult tissues
35Embryo tissues

Phenotypes

small testis1 supporting datasetCul4atm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
abnormal retina morphology1 supporting datasetCul4atm1b(EUCOMM)HmguhomozygoteEarly adult1.59x10-9 
abnormal testis morphology1 supporting datasetCul4atm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
increased circulating potassium level1 supporting datasetCul4atm1b(EUCOMM)HmguhomozygoteEarly adult1.01x10-5 
decreased circulating chloride level1 supporting datasetCul4atm1b(EUCOMM)HmguhomozygoteEarly adult7.59x10-7 
enhanced cued conditioning behavior1 supporting datasetCul4atm1b(EUCOMM)HmguhomozygoteEarly adult2.29x10-8 
male infertility1 supporting datasetCul4atm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
increased fasting circulating glucose level1 supporting datasetCul4atm1b(EUCOMM)HmguhomozygoteEarly adult1.91x10-5 
decreased mean platelet volume1 supporting datasetCul4atm1b(EUCOMM)HmguhomozygoteEarly adult4.54x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoteSection images
100% (2/2)0.7% (4/570)
aortaheterozygoteSection images
100% (2/2)0.19% (1/533)
bloodheterozygoten/an/a0% (0/17)
boneheterozygoteSection images
100% (2/2)0% (0/394)
bone marrowheterozygoten/an/a0% (0/22)
brainheterozygoteSection images
100% (2/2)0.86% (5/579)
brainstemheterozygoteSection images
100% (2/2)0.41% (2/490)
brown adipose tissueheterozygoteSection images
100% (2/2)0% (0/588)
cartilage tissueheterozygoteSection images
100% (2/2)0.22% (1/454)
cecumheterozygoteSection images
100% (2/2)7.75% (22/284)
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Human diseases caused by Cul4a mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

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Histopathology

IMPC related publications

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Cul4atm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)‌targeting vector
ES Cell
mouse
Cul4atm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)‌mouse
Cul4atm1e(EUCOMM)HmguTargeted, non-conditional allele‌ES Cell

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