Eif2s2 | eukaryotic translation initiation factor 2 subunit 2 beta

GeneMGI:1914454Synonyms: EIF2, D2Ertd303e, +3 more

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Immune system Vision/eye Hematopoietic system Behavior/neurological Mortality/aging

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, complete penetrance3 supporting datasetsEif2s2em3(IMPC)BayhomozygoteEarly adultN/A * 
abnormal spleen morphology1 supporting datasetEif2s2em3(IMPC)BayheterozygoteEarly adultN/A * 
persistence of hyaloid vascular system1 supporting datasetEif2s2em3(IMPC)BayheterozygoteEarly adult6x10-5 
hyperactivity2 supporting datasetsEif2s2em3(IMPC)BayheterozygoteEarly adult8.49x10-7 
embryonic lethality prior to organogenesis1 supporting datasetEif2s2em3(IMPC)BayhomozygoteE9.5N/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Eif2s2em1(IMPC)Baymouse
Eif2s2em2(IMPC)BayExon Deletionmouse
Eif2s2em3(IMPC)BayExon Deletionmouse
Eif2s2tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Eif2s2tm1e(KOMP)WtsiTargeted, non-conditional allelees cell

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