Fancl | Fanconi anemia, complementation group L
Physiological systems
17 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Pigmentation Immune system Integument Adipose tissue Growth/size/body region Hematopoietic system Skeleton
10 No significant impact
7 Not tested
Data collections
Gene metrics:9Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal coat/hair pigmentation | 5 supporting datasets | Fancltm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.63x10-6 | ||
| increased basophil cell number | 2 supporting datasets | Fancltm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.58x10-10 | ||
| decreased body length | 1 supporting dataset | Fancltm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.7x10-5 | ||
| decreased bone mineral content | 2 supporting datasets | Fancltm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.97x10-11 | ||
| decreased lean body mass | 2 supporting datasets | Fancltm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.02x10-5 | ||
| abnormal bone structure | 1 supporting dataset | Fancltm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.11x10-9 | ||
| decreased bone mineral density | 1 supporting dataset | Fancltm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.62x10-9 | ||
| increased eosinophil cell number | 2 supporting datasets | Fancltm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.39x10-11 | ||
| increased total body fat amount | 1 supporting dataset | Fancltm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.21x10-6 |
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Human diseases caused by Fancl mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Fancl.
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| Fancltm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Fancltm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Fancltm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |