Ssbp2 | single-stranded DNA binding protein 2
Physiological systems
21 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Reproductive system Adipose tissue Growth/size/body region Nervous system Vision/eye Behavior/neurological Cardiovascular system
14 No significant impact
3 Not tested
Data collections
Gene metrics:13Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| increased heart weight | 2 supporting datasets | Ssbp2tm1b(KOMP)Wtsi | homozygote | Early adult | 3.56x10-7 | ||
| increased startle reflex | 1 supporting dataset | Ssbp2tm1b(KOMP)Wtsi | homozygote | Early adult | 8.62x10-16 | ||
| abnormal eye morphology | 1 supporting dataset | Ssbp2tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| decreased brain weight | 1 supporting dataset | Ssbp2tm1b(KOMP)Wtsi | homozygote | Early adult | 3.87x10-7 | ||
| impaired pupillary reflex | 1 supporting dataset | Ssbp2tm1b(KOMP)Wtsi | homozygote | Early adult | 4.62x10-7 | ||
| hyperactivity | 4 supporting datasets | Ssbp2tm1b(KOMP)Wtsi | homozygote | Early adult | 1.98x10-5 | ||
| decreased total body fat amount | 1 supporting dataset | Ssbp2tm1b(KOMP)Wtsi | homozygote | Early adult | 4.14x10-7 | ||
| increased lean body mass | 1 supporting dataset | Ssbp2tm1b(KOMP)Wtsi | homozygote | Early adult | 3.1x10-8 | ||
| decreased grip strength | 1 supporting dataset | Ssbp2tm1b(KOMP)Wtsi | homozygote | Early adult | 2.19x10-5 | ||
| enlarged epididymis | 1 supporting dataset | Ssbp2tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 50% (1/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/1) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 50% (1/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images | 100% (2/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
Human diseases caused by Ssbp2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ssbp2.
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| Ssbp2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ssbp2tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ssbp2tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Ssbp2tm43066(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |