Trim59 | tripartite motif-containing 59
Physiological systems
20 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Vision/eye Mortality/aging
18 No significant impact
4 Not tested
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:51Adult tissues
62Embryo tissues
| decreased total retina thickness | 2 supporting datasets | Trim59tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.13x10-7 | ||
| abnormal retina outer nuclear layer morphology | 2 supporting datasets | Trim59tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 6.31x10-8 | ||
| preweaning lethality, incomplete penetrance | 2 supporting datasets | Trim59tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Wholemount images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | Wholemount images | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 100% (1/1) | 7.75% (22/284) |
| cerebellum | heterozygote | Wholemount images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Trim59 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Trim59.
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| Trim59tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Trim59tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Trim59tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |