Zfp474 | zinc finger protein 474
Physiological systems
21 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Limbs/digits/tail Hematopoietic system Cardiovascular system
13 No significant impact
3 Not tested
Data collections
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| enlarged heart | 1 supporting dataset | Zfp474em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| increased red blood cell distribution width | 1 supporting dataset | Zfp474em1(IMPC)Ccpcz | homozygote | Early adult | 5.4x10-5 | ||
| abnormal skin morphology | 2 supporting datasets | Zfp474em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| increased eosinophil cell number | 2 supporting datasets | Zfp474em1(IMPC)Ccpcz | homozygote | Early adult | 1.83x10-11 | ||
| small testis | 1 supporting dataset | Zfp474em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| increased neutrophil cell number | 2 supporting datasets | Zfp474em1(IMPC)Ccpcz | homozygote | Early adult | 5.39x10-7 | ||
| abnormal testis morphology | 1 supporting dataset | Zfp474em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal digit morphology | 1 supporting dataset | Zfp474em1(IMPC)Ccpcz | homozygote | Early adult | 6.83x10-14 | ||
| abnormal heart morphology | 1 supporting dataset | Zfp474em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| decreased lymphocyte cell number | 1 supporting dataset | Zfp474em1(IMPC)Ccpcz | homozygote | Early adult | 3.54x10-7 |
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Human diseases caused by Zfp474 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Zfp474.
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| Zfp474em1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Zfp474tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Zfp474tm279483(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Zfp474tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |