Dph6 | diphthamine biosynthesis 6
Physiological systems
18 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Pigmentation Integument Growth/size/body region Hematopoietic system Skeleton
11 No significant impact
6 Not tested
Data collections
Gene metrics:35Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
abnormal coat/hair pigmentation | 2 supporting datasets | Dph6tm1a(KOMP)Wtsi | homozygote | Early adult | 3.53x10-5 | ||
decreased CD8-positive, alpha-beta T cell number | 3 supporting datasets | Dph6tm1a(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
decreased CD8-positive, naive alpha-beta T cell number | 4 supporting datasets | Dph6tm1a(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
decreased Ly6C-positive mature NK cell number | 1 supporting dataset | Dph6tm1a(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
decreased NK T cell number | 1 supporting dataset | Dph6tm1a(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
decreased T-helper cell number | 1 supporting dataset | Dph6tm1a(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
decreased body length | 1 supporting dataset | Dph6tm1a(KOMP)Wtsi | homozygote | Early adult | 1.16x10-6 | ||
decreased effector memory CD8-positive, alpha-beta T cell number | 2 supporting datasets | Dph6tm1a(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
decreased erythrocyte cell number | 1 supporting dataset | Dph6tm1a(KOMP)Wtsi | homozygote | Early adult | 3.23x10-5 | ||
decreased hematocrit | 1 supporting dataset | Dph6tm1a(KOMP)Wtsi | homozygote | Early adult | 9.31x10-7 |
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External links
No external links available for Dph6.
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Dph6tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | ‌ | targeting vector ES Cell mouse |
Dph6tm1e(KOMP)Wtsi | Targeted, non-conditional allele | ‌ | ES Cell |