Dph6 | diphthamine biosynthesis 6

GeneMGI:1913882Synonyms: 5730421E18Rik, Atpbd4, +1 more

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Pigmentation Integument Growth/size/body region Hematopoietic system Skeleton

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:35Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal coat/hair pigmentation2 supporting datasetsDph6tm1a(KOMP)WtsihomozygoteEarly adult3.53x10-5 
decreased CD8-positive, alpha-beta T cell number3 supporting datasetsDph6tm1a(KOMP)WtsihomozygoteEarly adultN/A * 
decreased CD8-positive, naive alpha-beta T cell number4 supporting datasetsDph6tm1a(KOMP)WtsihomozygoteEarly adultN/A * 
decreased Ly6C-positive mature NK cell number1 supporting datasetDph6tm1a(KOMP)WtsihomozygoteEarly adultN/A * 
decreased NK T cell number1 supporting datasetDph6tm1a(KOMP)WtsihomozygoteEarly adultN/A * 
decreased T-helper cell number1 supporting datasetDph6tm1a(KOMP)WtsihomozygoteEarly adultN/A * 
decreased body length1 supporting datasetDph6tm1a(KOMP)WtsihomozygoteEarly adult1.16x10-6 
decreased effector memory CD8-positive, alpha-beta T cell number2 supporting datasetsDph6tm1a(KOMP)WtsihomozygoteEarly adultN/A * 
decreased erythrocyte cell number1 supporting datasetDph6tm1a(KOMP)WtsihomozygoteEarly adult3.23x10-5 
decreased hematocrit1 supporting datasetDph6tm1a(KOMP)WtsihomozygoteEarly adult9.31x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Histopathology

IMPC related publications

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Dph6tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)‌targeting vector
ES Cell
mouse
Dph6tm1e(KOMP)WtsiTargeted, non-conditional allele‌ES Cell

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