Atg4b | autophagy related 4B, cysteine peptidase
Physiological systems
19 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Limbs/digits/tail Hearing/vestibular/ear Vision/eye Nervous system Hematopoietic system Behavior/neurological Skeleton Craniofacial
8 No significant impact
5 Not tested
Data collections
Gene metrics:22Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| increased basophil cell number | 1 supporting dataset | Atg4bem1(IMPC)Marc | homozygote | Early adult | 1.48x10-5 | ||
| decreased blood urea nitrogen level | 1 supporting dataset | Atg4bem1(IMPC)Marc | homozygote | Early adult | 4.2x10-11 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Atg4btm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.87x10-8 | ||
| decreased circulating total protein level | 1 supporting dataset | Atg4btm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.09x10-5 | ||
| abnormal auditory brainstem response | 1 supporting dataset | Atg4bem1(IMPC)Marc | homozygote | Early adult | 8.75x10-5 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Atg4bem1(IMPC)Marc | homozygote | Early adult | 7.08x10-8 | ||
| decreased circulating total protein level | 1 supporting dataset | Atg4btm1b(EUCOMM)Hmgu | homozygote | Late adult | 1.67x10-7 | ||
| abnormal retina morphology | 1 supporting dataset | Atg4bem1(IMPC)Marc | homozygote | Early adult | 2.47x10-6 | ||
| increased leukocyte cell number | 1 supporting dataset | Atg4btm1b(EUCOMM)Hmgu | homozygote | Late adult | 1.79x10-5 | ||
| limb grasping | 1 supporting dataset | Atg4btm1b(EUCOMM)Hmgu | homozygote | Late adult | 1.5x10-6 |
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| adrenal gland | heterozygote | n/a | 0% (0/1) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 50% (1/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 50% (1/2) | 1.67% (7/419) |
Human diseases caused by Atg4b mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Atg4b.
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