Cmpk1 | cytidine/uridine monophosphate kinase 1
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Vision/eye Cardiovascular system Mortality/aging Renal/urinary system
14 No significant impact
4 Not tested
Data collections
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| polycystic kidney | 1 supporting dataset | Cmpk1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Cmpk1tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Cmpk1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.98x10-5 | ||
| increased circulating iron level | 1 supporting dataset | Cmpk1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 9.3x10-5 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Cmpk1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 6.61x10-5 |
| | | | | | | | | | |
Human diseases caused by Cmpk1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cmpk1.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Cmpk1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Cmpk1tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Cmpk1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |